Flag Officer Foote initially commanded the Union naval forces, which were later led by Farragut and Porter.
This cut the main east-west artery of transportation for the South, depriving the rest of the Confederacy of men, food and other supplies from the Confederate States west of the river.
While not commonly lumped together under this designation, the river campaigns were undertaken mainly for reasons found in Union General-in-Chief Winfield Scott's 1861 Anaconda Plan.
The only exception was at the Siege of Vicksburg where the army, marching downstream met up with the Union Navy under Rear Admiral David Farragut sailing upstream and the two combined their forces for an all-out land-and-sea shelling of the town.
Important battles in the Tennessee and Cumberland Rivers campaign were the capture of Fort Henry and Fort Donelson, where the Union forces were under the direct command of Brigadier General U.S. Grant, who reported to Major General Halleck, and the naval forces of the Western Gunboat Flotilla, predecessor of the Mississippi River Squadron, were led by Flag Officer Andrew H. Foote.