Route 150 is a highway on the south side of the Kansas City, Missouri Metro Area.

The highway initially heads southeastward, but soon turns towards the east and passes along the northern boundary of the former Richards-Gebaur Air Force Base.

Route 150 bypasses the James A. Reed Memorial Wildlife Area to the south, and its local name changes several times.

The roughly half-mile south–north concurrency ends when Route 150 bears east through rural land.

It turns due north on South Bynum Road once in Lone Jack and eventually terminates at US 50.