Route 58 is a highway in western Missouri.

Its eastern terminus is at U.S. Route 50 west of Warrensburg; its western terminus is at Route D west of Belton, Missouri.

It is one of only a very few highways to end at a state supplemental route.

Route 58 is one of the original 1922 state highways.

In the 1950s, Route 58 had a spur connecting it with north US 71.