It runs east for a short time before turning to the northeast and intersecting Route DD.

The highway heads farther northeast and meets Route 64 in Pumpkin Center.

North of the Route 64 intersection, the highway runs through Tunas.

[6] Sometime between 1932 and 1935, US 54 was realigned to the north (switching places with Route 64), rejoining its old alignment west of Macks Creek.

The diagonal section cut off between Buffalo and Macks Creek became Route 73.