[4] Among the alumni of the Missouri School are the blind musicians Nat Brown, John William Boone (1864–1927)[5] and Louis Hardin, aka "Moondog" (1916–1999).

[2] Modern classrooms are augmented with technologically advanced tools including BrailleNotes and other computers with refreshable Braille displays and text-to-speech functions.

It remains in the city of St. Louis, fully operated by the Missouri Department of Elementary and Secondary Education (DESE).

[9] The braille system of writing had been slow to develop in the United States, but was introduced at the Missouri School in the late 1850s by a member of its board of directors, Dr. Simon Pollak.

Eventually, however, the students themselves took up Pollak's cause and found an enthusiastic spokesman in the school's music department chairman, Henry Robyn.

"[10] The Missouri School was the first educational institution in the United States to recognize braille as the primary system for blind persons' instruction.