[1][2] Born in Catania, Italy, she moved to Montreal, Quebec, Canada at the age of eight and has resided in the city ever since.

[4] After drumming in bands since the age of twelve, she began DJing in 1996 and established record label Relentless in 1999.

In 2006, she released the mix album Come with Me....[6] In 2009 she released the debut artist album as a singer, I'm No Human,[7][8] which was nominated for a 2010 Juno Award for Best Dance Recording of the Year, and included the single "I'm Running", featuring fellow Montreal musician Sam Roberts.

"I'm No Human" was born out of unhappy circumstances, sparked by the death of a close family member features Misstress Barbara step from behind the turntables in front of the microphone and was recorded in her home town of Montreal.

In July 2012, she sang her single "The Right Time" at Parliament Hill during Canada Day celebrations and later in that same month she was back at Le Festival International de Jazz de Montréal, at La Société des Arts Technologiques (SAT), to perform her new live show Many Shades of Grey.