Mista Thug Isolation is the debut studio album by American rapper Lil Ugly Mane.

[1] The album is entirely self-produced as Shawn Kemp, with guest appearances from Supa Sortahuman and Denzel Curry.

The album attracted attention in the underground hip hop scene for its Memphis rap-inspired sound and would bring Lil Ugly Mane to mainstream popularity after also previously appearing on SpaceGhostPurrp's debut mixtape Blackland Radio 66.6 in 2011.

Members of hip hop collective Odd Future Tyler, the Creator[2] and Earl Sweatshirt showed support for Lil Ugly Mane and the album, specifically the song "Throw Dem Gunz".

[3] The songs "Radiation (Lung Pollution)", "Lookin 4 Tha Suckin", and "Twistin" were previously on Lil Ugly Mane's 2012 mixtape Criminal Hypnosis: Unreleased Shit.