This river flows into the Mistissini (Cree village municipality), into the Albanel Lakes Wildlife Reserve, Mistassini and Mistago and into the Assinica Wildlife Sanctuary.

The hydrographic slope of the Mistago River is accessible by a forest road (North–south direction) which cuts the river and connects to route 167 south-west of Waconichi Lake; the latter road comes from Chibougamau, going north-east along the southeast shore of Waconichi Lake and the river of the same name.

The surface of the "Mistago River" is usually frozen from early November to mid-May, however traffic Ice safety is usually from mid-November to mid-April.

The "Mistago River" originates at the mouth of an unidentified lake (length: 0.4 kilometres (0.25 mi); 419 metres (1,375 ft)) in the Mistissini (Cree village municipality).

The latter is crossed to the northwest by the Waswanipi River which is a tributary of Matagami Lake.