The route 404, connecting the village of Clova, Quebec with the South Bay of Bureau Lake (Gouin Reservoir) also serves the upper part of the river Wistatikamekw; this road connects to the south-east the route 400 which goes to Gouin Dam.

The surface of the Mistatikamekw River is usually frozen from mid-November to the end of April, however, safe ice circulation is generally from early December to late March.

The Mistatikamekw River originates at the mouth of an unidentified lake (length: 1.3 kilometres (0.81 mi), altitude: 454 metres (1,490 ft)), located north-west of Lac Dugré.

From there, the current runs on 145.5 kilometres (90.4 mi) until Gouin Dam, according to the following segments: The hydronym "Mistatikamekw" is of autochthonous origin.

The toponym "Mistatikamekw River" was formalized on September 3, 1981, at the Commission de toponymie du Quebec.