This adaptation was developed by K. J. Steinberg, and stars Alyssa Milano, Rochelle Aytes, Yunjin Kim, Jes Macallan, and Jennifer Esposito in the lead roles.

[16] On September 30, 2014, ABC renewed the series for a third season with production of the program being moved from Los Angeles to Vancouver, British Columbia.

[14] Aytes portrays April, a widow and mother of one, while Macallan plays Josslyn, a real estate broker and the youngest of the women.

[23] On February 10, 2015, it was confirmed that actress Jennifer Esposito would join the cast as the new co-lead Calista Raines, described as the creative director of a luxury fashion brand.

[25] Brian Lowry of Variety was quite optimistic about the series, stating: "A frothy prime time soap with a definite naughty streak, the program looks well suited to scratch an itch for daytime serial fans ABC abandoned."

Rabinowitz also stated that "the really delectable fun, the best of the sparkle, is to be found in the darkest plots, the looming catastrophes, which promise to come in an endless flow.

"[27] In less positive reviews, New York Daily News' David Hinckley gave the premiere two out of five stars, stating that "ABC loves racy romantic dramas, but Mistresses is not its best work in the genre."

Steinberg is "grasping the letter yet not the spirit of the thing, appears more interested in replicating plot from the British version rather than character or anything like nuance."