Her most prominent appearances includes; sci-fi television series Space City Sigma (1989-1991), Pachpan Khambe Laal Deewarein, Swabhimaan, Devyani in Kuch Khatti Kuch Meethi,Alaan (Kirdaar) to Trishna in Kahani Ghar Ghar Ki and Jethi Maa in Kaala Teeka to film roles with a wide spectrum of directors with different cinema styles.

She graduated from the National School of Drama (Delhi) in 1987 and did her post-graduation in literature from Punjab University, Chandigarh.

In June 2001, Vashisht established Mandala, which is a space for arts collaborations research and education.

[citation needed] As artistic director of Mandala she created Mandala TAM (theatre arts module), which is a methodology and a training process based on the performing arts that proved to be highly successful in helping the trafficked minors to heal and transform mentally, physically, emotionally and intellectually.

In 2012 she directed the documentary film She, of the Four Names, commissioned by Public Services Broadcasting Trust, India.

[10] She was appreciated by the audience for her negative portrayal of Jethi Maa from TV Series Kaala Teeka.