[3] He voiced DJ in the animated film, Monster House, and starred as Raymond Figg in the Disney Channel Original Movie, Life Is Ruff, released in 2005.

In addition to his role as Oliver Oken in Disney Channel's Hannah Montana, Musso also voiced Jeremy Johnson in Phineas and Ferb, a boy on whom the title characters' sister, Candace (Ashley Tisdale) has a crush.

Other acting credits include Raymond Figg in the Disney Channel Original Movie, Life Is Ruff, the voice of Aang in the unaired version of the pilot episode of Avatar: The Last Airbender, the voice of DJ in the film Monster House, and Hannah Montana: The Movie, which was released on April 10, 2009.

He also appeared in the television film Walker, Texas Ranger: Trial by Fire alongside Chuck Norris and Selena Gomez.

On June 2, 2008, Musso was a surprise guest at the Spotlight Awards at the North Shore Music Theatre in Beverly, Massachusetts.

In early 2009, Musso was cast, alongside The Suite Life on Deck and House of Payne's Doc Shaw, in a new television series for Disney XD titled Pair of Kings.

It was announced that Musso would be the host of Disney Channel's latest hidden camera reality series, PrankStars, which premiered on July 15, 2011.

For their 2009 Disney Channel Original Movie, Hatching Pete, Musso teamed up with co-star Tiffany Thornton, from Sonny with a Chance, to record a song called "Let It Go" that was used in the film.

Musso also recorded a song called "The Girl Can't Help It" for another Disney Channel Original Movie, Princess Protection Program.

[12] On 23 September 2022, after a ten-year hiatus, Musso returned to the music industry, releasing a new single, titled, "DRANK", for his upcoming mixtape, Ghost.

[15] On October 17, 2011, at 3:43 a.m., Musso was pulled over in Burbank, California, failed to slow down for traffic cops, and charged with a DUI suspicion.

It was discovered that Musso allegedly had multiple outstanding warrants, and was subsequently taken into police custody in Rockwall, Texas.

Musso faced charges of "public intoxication, theft (under $100), expired registration, failure to display a driver's license, and violating a promise to appear notice.