The Mitchell Building-First State Bank Building, at 222 Knox Street in Barbourville, Kentucky, is a Romanesque Revival-style building built in 1910.

[1] It is a three-story masonry wall and wood-frame building, with a Romanesque brick arch entry as its most salient feature.

The brickwork is in common bond with a quoin detail every sixth course.

[2] It was deemed notable as "the best example of the Romanesque Revival style in Barbourville.

This article about a property in Knox County, Kentucky on the National Register of Historic Places is a stub.