The Mitchell Micropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties in South Dakota, anchored by the city of Mitchell.

[1] As of the census[2] of 2000, there were 21,880 people, 8,700 households, and 5,618 families residing within the μSA.

The racial makeup of the μSA was 96.70% White, 0.23% African American, 1.71% Native American, 0.38% Asian, 0.02% Pacific Islander, 0.26% from other races, and 0.69% from two or more races.

Hispanic or Latino of any race were 0.61% of the population.

Males had a median income of $28,969 versus $20,578 for females.