Mithridates II Antiochus Epiphanes Philorhomaeus Philhellen Monocrites (Greek: Μιθριδάτης Ἀντίοχος ὀ Ἐπιφανής Φιλορωμαίος Φιλέλλην Μονοκρίτης, died 20 BC), also known as Mithridates II of Commagene, was a king of Commagene in the 1st century BC.

Of Iranian[1] and Greek descent, he was one of the sons of King Antiochus I Theos of Commagene.

In 31 BC, Mithridates personally led his forces to Actium in Greece in support of Antony in the war against Caesar Octavian, the future Roman emperor Augustus.

Nevertheless, Augustus forced Mithridates to hand over a village in Commagene called Zeugma, which was a major crossing point of the Euphrates River, to the Roman province of Syria.

Mithridates had a brother, Antiochus II of Commagene, who was also a prince of the kingdom.