[1] After Mithridates attained manhood, he married Laodice, a sister of Antiochus Hierax and Seleucus II Callinicus, with whom he is said to have received the province of Phrygia as a dowry.
In 245 BCE Antiochus Hierax, supported by his mother Laodice I who held influence in Anatolia,[2] demands the possession of Anatolia (Asia Minor) from his brother Seleucus II Callinicus and quickly declares his independence in order to expand his territory and his authority.
In 222 BCE, Mithridates II gave his daughter Laodice in marriage to the Seleucid king Antiochus III.
[3] In 220 BC, Mithridates declared war upon the wealthy and powerful city of Sinope.
[4] In 227 BC, Mithridates II vied with the other monarchs of Asia in sending magnificent presents to the Rhodians, after the destruction of their city by an earthquake.