She is best known for starring in the television series Three Busy Debras, based on the sketch comedy group she co-founded, and voicing Cleopatra "Cleo" Smith in the second and third seasons of Clone High.

[2] She contributes writing to the website The Reductress, and has written for the television series High Maintenance, Miracle Workers, and Big Mouth.

[2] In 2015, Jouhari co-founded the sketch comedy trio Three Busy Debras alongside Sandy Honig and Alyssa Stonoha.

[10] In 2015, Jouhari and Catherine Cohen, later joined by Patti Harrison, started co-hosting It's A Guy Thing, a monthly show in Brooklyn.

[13] In 2023 she was cast as the new voice of Cleopatra "Cleo" Smith in the second season of Clone High replacing Christa Miller on the Max streaming service.