Mixto is also the most successful football club of Mato Grosso, having won twenty-four Campeonato Matogrossense titles.

[2] In 1976, the club competed in the Campeonato Brasileiro Série A for the first time, finishing in the 27th position.

With their 1984 state title, the club gained promotion to the 1985 Serie A, where the club had its best campaign in history, finishing in 14th place, above other G-12 teams like Gremio, Corinthians, Fluminense, Santos, and Sao Paulo.

[1][4] However, a CBF league restructuring caused their "relegation" to Serie B in 1986 with the 1986 Parallel Tournament [pt], where 36 teams were divided into group of 9, with only the four group winners remaining in the Serie A.

In 2008, the club won the state league for the first time since 1996 with a 1-0 victory on aggregate over União Rondonópolis.