Between world wars, Mizocz was a multi-ethnic community like many others in eastern Poland, inhabited by Jews, Poles, and Ukrainians.

There was a military school in Mizocz for the officer cadets of the Battalion 11 of the Polish Army's First Brigade;[2] the Karwicki Palace (built in 1790, partly destroyed by the Bolsheviks in 1917), Hotel Barmocha Fuksa,[3] a Catholic and an Orthodox church, and a Synagogue.

The Jewish inhabitants were first forced into the newly formed Mizocz Ghetto, from which they were taken out and slaughtered at a nearby ravine.

The Jews who managed to escape the mass executions hid with villagers they knew, tried to survive in the forests or joined various partisan units.

As a result of constant raids by the Germans and the auxiliary police, frequent denunciations by individual villagers, and the Ukrainian-Polish conflict, very few Jews survived to experience the end of the Nazi occupation in 1944.