USSOCOM has adopted the weapon and started its fielding process, beginning with special operations units.

The Mk 48 was designed in the early 2000s, following a request from United States Special Operations Command for a replacement for the M60.

The design is based on an early 7.62×51mm NATO prototype of the FN Minimi, modified to be a scaled-up version of the 5.56 mm Mk 46 Mod 0.

The disadvantages of Mk 48 Mod 0 are that the life of the receiver is only about half of the M240B, and the effective range with accuracy are slightly lower than the M240B.

The Mk 48 Mod 0 is currently in service with certain USSOCOM units, such as the U.S. Navy SEALs and Army's 75th Ranger Regiment.