In this episode, Homer, Reverend Lovejoy, and Apu Nahasapeemapetilon receive a letter from Moe stating that he will steal one of their wives.
The episode was written by Stephanie Gillis and directed by Matthew Nastuk and guest stars Don Pardo as himself.
"Moe Letter Blues" received positive reviews from critics and was viewed by 5.66 million households according to the Nielsen Media Research.
Mother's Day is approaching, and Marge, needing a break, suggests Homer take the children to Weasel Island after Krusty promotes it.
As the ferry to the island departs, the three men receive a letter from Moe saying he is running off with one of their wives.
Apu notices cracks in his marriage, recollecting an incident where he and Manjula forgot their son at Moe's after using the bar's bathroom.
When Lovejoy arrives home, he too thinks Helen is leaving, but she surprises him with tickets to Istanbul on board the Orient Express.
Moe reveals he saw how troubling the relationships were, so he organized Marge's portrait, the Lovejoys' trip, and the Nahasapeemapetilons' marriage rescue.
The Itchy and Scratchy cartoon in the episode is a reference to the black and white French film A Trip to the Moon, and includes the song "Maple Leaf Rag" by ragtime composer Scott Joplin.
Otto's state of hallucination makes him see, during the drive from Weasel Island back to Springfield, characters from the Disney Pixar animated film Cars.
In its original American broadcast, "Moe Letter Blues" was viewed by an estimated 5.660 million households, received a 2.7 rating/9 share in the 18-49 demographic tying with last week, coming second in its time slot losing to the season finale of The Amazing Race and becoming the third highest rated show on "Animation Domination.
TV Fanatic gave the episode 3.5/5 and stated "The flashbacks definitely had some hilarious moments including a thousand devils d'ohing on Homer's shoulder.