The Moe River is a watercourse flowing in the administrative region of Estrie to Quebec, Canada.

From Head Lake, the course of the Moe River descends on 36.7 kilometres (22.8 mi) with a drop of 302 metres (991 ft) in the following segments: Fed by several small streams at the foot of Mount Hereford, the Moe River follows a very narrow and winding course, passes through the village of Compton and is a branch of the rivière aux Saumons (Massawippi River tributary) (not to be confused with the rivière au Saumon (Le Haut-Saint-François)); it flows into the Massawippi River, near Lennoxville which is merged with Saint-François River, in Sherbrooke, in Estrie.

[1] The name of this watercourse perpetuates the memory of Austin Moe, a native of Vermont who settled in Ascot Township in 1795.

Despite the francization of the generic, the spelling of the English toponym, by omitting the apostrophe, that is to say Moes, was perpetuated for a certain time.

[2] The toponym "rivière Moe" was made official on December 13, 1996, at the Commission de toponymie du Québec.