The series stars R&B singer Brandy as Moesha Denise Mitchell, an African-American teenager living with her upper middle class family in the Leimert Park neighborhood of Los Angeles.

The series focused on the life of a black upper-middle-class family through the eyes of a typical girl named Moesha.

The show dealt with real social issues affecting teenagers, such as premarital sex, the death of a parent, teen pregnancy, drug use, race relations, sexuality, dementia, and day-to-day issues teenagers faced at home and school such as gender prejudice and inequality.

Season 4 showed the cast around the neighborhood and Moesha, Kim, and Niecy dancing at the fountain while wearing red outfits.

Season 5 showed the cast dancing in a panoramic view as Norwood lip-syncs to the theme song on a background of clouds and a rising sun.

Since Yvette Wilson left Moesha to join the cast of The Parkers and Sheryl Lee Ralph's character Dee became a recurring character, the season 6 opening features footage of Norwood lip-syncing over the portion of the theme song where Yvette Wilson and Sheryl Lee Ralph appeared in the previous season's opening.

Given her popularity for four seasons on Moesha, Countess Vaughn left the show in 1999 for her spin-off, The Parkers, which premiered on August 30, 1999, on UPN.

Leaving Moesha, Yvette Wilson joined the cast of The Parkers as Andell Wilkerson, Nikki's childhood friend.

Several Moesha cast members (including Brandy Norwood, William Allen Young, Shar Jackson, Sheryl Lee Ralph, and Marcus T. Paulk) made crossover appearances on The Parkers.

The Melanie and Derwin characters re-appeared in the Girlfriends Season 7 finale episode at Joan's engagement party.

It also aired on Nickelodeon from 1996 to 2000, who only showed episodes from the first four seasons which were edited so they would be more suitable for broadcast on children's television.

Since 2008, the show has aired in international syndication in Spain, Portugal, Israel, the Middle East, Russia, France, Germany, Austria, the Netherlands, Belgium, Ireland, South Africa, Latin America, Brazil, and Australia.

[17][18][19] On September 27, 2011, CBS Home Entertainment released Moesha: The First Season on DVD in Region 1 via Amazon.com's CreateSpace program.