In 1967, when he was 18, Tarigami and his friend Ghulam Nabi Malik, now the J&K secretary of the CPI(M), organised a protest to demand an increase in intake capacity at Anantnag Degree College.

After the 1975 Indira-Sheikh Accord, under which Jammu and Kashmir was made a constituent unit of the Union of India, Tarigami demanded the right to self-determination, and his activism landed him in jail.

[9] In 1979, when the execution of former Pakistan PM Zulfikar Ali Bhutto led to riots in Kashmir, Sheikh Abdullah, confronted Marxists and Tarigami became among the first people to be booked under the controversial Public Safety Act (PSA).

[6] In the aftermath of the Bhutto episode, both Malik and Tarigami rejoined the CPI(M) and restarted their journey in Kulgam as mainstream politicians.

In 2005, militants entered the heavily guarded Tulsibagh colony in Srinagar and attacked the homes of Tarigami and the Minister for Education Ghulam Nabi Lone.

[12] In 2016, he slammed the former MP Tariq Hameed Karra for resigning from Lok Sabha membership and said he should have raised the Kashmir issue in Indian Parliament.

[12] In August 2019, CPI(M) General Secretary Sitaram Yechury filed a Habeas corpus petition in Supreme Court to find Mohammed Yusuf Tarigami, who was targeted by Jammu & Kashmir authority.

[21] He slammed the modi Government for detaining former Jammu and Kashmir Chief Minister Farooq Abdullah under the Public Safety Act.

[27][28] He called on Jammu and Kashmir Lieutenant Governor Manoj Sinha and raised the issue of the encounter in Srinagar’s Hokersar-Lawaypora.

[29] He demanded an impartial and time-bound probe into the incident in which three youths including a 17-year-old from South Kashmir’s Pulwama and Shopian districts were killed on December 30 inside a house in Hokersar on the outskirts of Srinagar by the security forces in an encounter.

[29] He slammed New Delhi and the UT administration for utilising the pandemic and security induced lockdown to pass contentious laws without consultation, confident that there would be no resistance.

[30] Tarigami argued that there was no need for the J&K administration to constitute a special task force (STF) to deal with government employees allegedly involved in “anti-national activities” as there were already enough provisions in the law to act against such people.

[32] Further, he urged the government to provide adequate incentives and wages to ASHA workers on the pattern of COVID-19 warriors of the Health and Medical Education Department.