He played college football for the Georgia Bulldogs and was selected by the Cleveland Browns in the second round of the 2009 NFL draft.

[1] During his four years there his team did not lose a single game and won four straight state championships.

He finished his collegiate career at the University of Georgia with 158 catches for 2,282 yards and 16 touchdowns, which ranks fourth best in school history.

His longest reception came in his junior season against SEC East rival Florida, hauling in an 84-yard touchdown pass from quarterback Matthew Stafford.

[8] In April 2017, Massaquoi had an ATV accident which led to the amputation of four fingers on his left hand.