His father, Alhaj Mawlana Ghazi Abdul Bari Khan, was a disciple of Sayyid Ahmad Shahid and participated in the Battle of Balakot.

From October 1936, Akram Khan began publishing the newspaper The Azad, which generated support for the Muslim League in Bengal.

He was elected secretary of the All India Khilafat Committee at the conference held at Ahsan Manzil in Dhaka in 1920, which was attended by other eminent Khilafat Movement leaders like Abul Kalam Azad, Maniruzzaman Islamabadi and Mujibur Rahman.

During 1920–1923, he organised public meetings in different parts of Bengal to propagate the cause of the Khilafat and the Non-cooperation Movement.

As a believer in Hindu-Muslim amity, Akram Khan supported Chitta Ranjan Das's Swaraj Party in Kolkata in 1922, and also the Bengal pact in 1923.

[7] He was also a founding member of Pakistan's Council of Islamic Ideology, a constitutional body formed in 1962.