Early in his reign, his approval of the Berber Dahir drew widespread backlash and spurred an upsurge of Moroccan nationalism and opposition to continued French rule.
During World War II he supported the Allies, participated in the 1943 Anfa Conference and took steps to protect Moroccan Jews from Vichy persecution.
In 1947, he delivered a historic speech in Tangier, in which he made an open appeal for Moroccan independence and emphasized the country's ties with the rest of the Arab world.
[7] On 18 November 1927, a "young and timid" 17-year-old Muhammad bin Yusef was enthroned after the death of his father and the departure of Hubert Lyautey.
[8] On 22 January 1943, he met privately with the US president Franklin Delano Roosevelt and the Prime Minister of the UK Winston Churchill.
"[8] The sultan's 14-year-old son and future king of Morocco, Hassan II, also attended and later stated that Roosevelt said, "Ten years from now your country will be independent.
[12] The sultan's stand was "based as much on the insult the Vichy diktats posed to his claim of sovereignty over all his subjects, including the Jews, as on his humanitarian instincts.
[14] Some historians maintain that Mohammed's anti-Nazi role has been exaggerated; historian Michel Abitol writes that while Mohammed V was compelled by Vichy officials to sign the anti-Jewish dahirs, "he was more passive than Moncef Bay (ruler of Tunisia during the Second World War) in that he did not take any side and did not engage in any public act that could be interpreted as a rejection of Vichy's policy.
"[13] Sultan Mohammad was a central figure in the independence movement in Morocco, also known as the Revolution of the King and the People (ثورة الملك والشعب).
Further demonstrations turn into riots in Morocco in 1952, notably in Casablanca, while Sidi Mohammed gives the Moroccan cause an international audience at the UN with the support of the United States.
[18] On 20 August 1953 (the eve of Eid al-Adha), the French colonial authorities forced Mohammed V, an important national symbol in the growing Moroccan independence movement, into exile in Corsica along with his family.
His first cousin once removed, Mohammed Ben Aarafa, called the "French sultan," was made a puppet monarch and placed on the throne.
[20] The situation became so tense that in 1955, the Moroccan nationalists, who enjoyed support in Libya, Algeria (with the FLN) and Egypt forced the French government to negotiate and recall the sultan.
This visit marked a strategic effort to align Morocco closely with the US, showcasing the monarchy's importance on the global stage.
[24] Mohammed V also acted as patron to the International Meetings, conferences on contemporary issues and interfaith dialogue hosted at the Benedictine monastery of Toumliline that attracted scholars and intellectuals from all over the world.
[25] During his reign, the Moroccan Liberation Army waged war against Spain and France, and successfully captured most of Ifni as well as Cape Juby and parts of Spanish Sahara.
With the treaty of Angra de Cintra, Morocco annexed Cape Juby and the surroundings of Ifni, while the rest of the remaining colony was ceded by Spain in 1969.
In December 2007, The Jewish Daily Forward reported on a secret diplomatic initiative by the Moroccan government to have Mohammed V admitted to the Righteous Among the Nations.