Sheikh Mohammed also heads the Council of Ministers sessions, including managing discussions and supervising the coordination of work between ministries to achieve unity between governmental agencies and ensure the integration of their activities.

[11][12] Sheikh Mohammed met with CIA Director William J. Burns and head of Mossad David Barnea in Qatar in November.

[19] In late January 2024, Sheikh Mohammed met US officials in an effort to continue ceasefire negotiations in Washington, D.C.[20] and welcomed US Secretary Blinken in Doha on 6 February 2024.

[28] The TIME magazine recognizes Qatar's adeptness in managing diverse interests, exemplified by its hosting of a significant US air base and a Taliban office.The decision was further shaped by the Prime Minister's role as a mediator in various regions grappling with difficulties, including South America.

"Moreover, before October 7, the 43-year-old prime minister had received commendation from US officials for his adeptness as a mediator in numerous complex scenarios, including those in South America," it stated.

[29][30] In January 2025, Sheikh Mohammed bin Abdulrahman Al Thani facilitated negotiations that led to a cease-fire agreement between Israel and Hamas after over a year of conflict in Gaza.

Under his mediation, Qatari officials hosted talks in Doha, resulting in a truce involving a prisoner exchange and measures to address the humanitarian situation in the region.

Al Thani pledged Qatar's active involvement in Lebanon's reconstruction, particularly in the southern region affected by the recent conflict with Israel.

Sheikh Mohammed contributes to supporting international development through the fund's long-term strategy[34] focusing on education, health, economic empowerment, and addressing climate change.

Sheikh Mohammed's leadership has contributed to strengthening ties with recipient countries and Qatar's prominent efforts overall to coordinate international multilateral action.

[40] Qatar's Minister of State for Foreign Affairs, Sultan bin Saad Al Muraikhi,[41] received the honor on behalf of Sheikh Mohammed.