During his four-year career as a pirate, he served as an officer under l'Ollonais and formed a brief partnership with Pierre Le Picard.

Vauquelin was one of several officers serving in this expedition and was present at the raids against Maracaibo and Gibraltar in 1666 and Puerto de Cavallo and San Pedro in 1667. l'Ollonais and his fleet eventually split up, arguing over l'Ollonais desire to sail for Guatemala, shortly after the capture of a Spanish ship off the coast of the Yucatán.

He and Pierre le Picard chose to leave the expedition, some accounts suggesting they were the ringleaders and instigators of the fleet's disbandment,[1] and began privateering together for a time.

He and his crew were able to successfully capture a Spanish prize, carrying a large cargo of cacao, near the port of Havana, Cuba before returning to Tortuga.

The book contained detailed information of the geography of the Caribbean and West Indies, particularly the coasts of Honduras and the Yucatán, which were used by the Royal French Navy as well as later buccaneers.