Mokama is connected to metropolitan areas of India, by the Delhi–Kolkata main line via Mugalsarai–Patna route.

Due to its location on the Howrah–Patna–Mughalsarai main line many Patna, Barauni-bound express trains coming from Howrah, Sealdah, Ranchi, Tatanagar stop here.

Mokama station is an important of the Danapur division as it links, Assam through the Mokama–Barauni section and North Bihar by the Rajendra Bridge on the Ganga river.

The Mokama–Kiul section has optical fibre for improved communication and railway safety.

Many passenger and express trains serve Mokama station.