Close cooperation between the Central Rada of the Ukrainian People's Republic and the Sfatul Țării of the Moldavian Democratic Republic in November–December 1917 was evidenced by the fact that the first meeting of the Moldovan Parliament was held on November 21, 1917 in Chisinau under the protection of "national Moldavian and Ukrainian troops."

After the declaration of the independent Ukrainian People's Republic, its government, defining the state borders, paid special attention to that with Moldova.

[2] The situation remains unresolved with one block of the Cuciurgan power station, as it considered to be on Moldovan territory today for unclear reasons, or at least contested by Ukraine.

Ukraine had transferred 400 meters (yards) of the Ukrainian bank of the Danube to Moldova in 1997, in order to make the construction of the terminal possible.

[3] Despite this, the government maintained cordial relations with Kyiv, with Prime Minister of Moldova Pavel Filip holding a phone call with his Ukrainian counterpart Volodymyr Groysman a month after Dodon's election, during which he confirmed that Moldova stands for the preservation of the sovereignty of Ukraine.

[4] In January 2017, Dodon stated that Moldova would not officially recognize the annexation of Crimea by Russia as legal, reneging on statements he made to the contrary in October 2016 on the issue, stressing his position that "we need to build friendships with Ukraine".

[10] On 24 February 2022, President Sandu condemned the Russian invasion of Ukraine[11] as a "a blatant breach of international law and of Ukrainian sovereignty and territorial integrity",[12] adding that "we will help people who need our help and support.