27 entries competed to represent Moldova in Lisbon, with 16 being shortlisted to participate in the televised national final which took place on 24 February 2018 after auditioning in front of a jury panel.

"My Lucky Day" performed by DoReDoS emerged as the winner after gaining the most points following the combination of votes from a jury panel and a public televote.

Performing during the show in position 7, "My Lucky Day" was announced among the top 10 entries of the second semi-final and therefore qualified to compete in the final on 14 May.

[3] O melodie pentru Europa 2018 was the national final format developed by TRM in order to select Moldova's entry for the Eurovision Song Contest 2018.

The event took place at the TRM Studio 2 in Chișinău, hosted by Sergiu Beznițchi and Evelina Vîrlan with Djulieta Gînu-Ardovan reporting from the green room, and included a final to be held on 24 February 2018.

Artists could submit more than one song, and an international act was able to compete only if they were part of a duo or group where 50% of the lead vocalists were of Moldovan nationality.

[3] At the conclusion of the submission deadline, 27 valid entries out of 28 were received by the broadcaster; "Let's Start Together Right Now" performed by Pelageya Stefoglo was disqualified as the song had also been submitted for the 2018 Belarusian Eurovision national final.

[5][6] The live audition round took place on 1 February 2018 at the Karaoke Concert Hall Atrium in Chișinău where 16 finalists were selected to advance.

Sixteen songs competed and the winner was selected based on the combination of a public televote and the votes of an expert jury.

[12] On 7 April, DoReDoS performed during the Eurovision Pre-Party, which was held at the VEGAS Kuntsevo shopping mall in Moscow, Russia.

[14] On 14 April, DoReDoS performed during the Eurovision in Concert event which was held at the AFAS Live venue in Amsterdam, Netherlands and hosted by Edsilia Rombley and Cornald Maas.

The stage featured a white box with small doors that were opened and closed to reveal the arms, legs, and faces of the performers, of which Mîța and Djundyet walked around at the beginning.

Each nation's jury consisted of five music industry professionals who are citizens of the country they represent, with their names published before the contest to ensure transparency.

This jury judged each entry based on: vocal capacity; the stage performance; the song's composition and originality; and the overall impression by the act.