Before the Soviet occupation of Bessarabia and Northern Bukovina in 1940, clubs from modern Moldova competed in the Romanian football competitions, particularly Nistru Chișinău.

At the end of the season, the bottom club is relegated to Liga 1 and replaced by the lower league's champion.

Sheriff Tiraspol – located in Transnistria – is the most successful league club with 21 titles, followed by Zimbru Chișinău with eight wins.

Petrocub Hîncești, Milsami Orhei, Dacia Chișinău and FC Tiraspol also won the title on one occasion each.

Teams in bold are currently playing in Moldovan National Division (2023-24 season).