The village of Molesworth was designated a conservation area by Huntingdon District Council largely due to its typically rural English character that includes several listed buildings.

In 1646, two people from Molesworth, John Winnick and Ellen Shepheard (along with others from the nearby village of Catworth) were examined as witches.

[4] The village gives its name to RAF Molesworth, a Royal Air Force station dating back to 1917.

It is the home to the Joint Analysis Center, the intelligence fusion centre supporting the United States European Command and NATO.

In 1085 William the Conqueror ordered that a survey should be carried out across his kingdom to discover who owned which parts and what it was worth.

[7] The lands belonged to a "Eustace the Sheriff"; the tenant in chief was held by Countess Judith who was a niece of William the Conqueror.

The Domesday Book uses a number of units of measure for areas of land that are now unfamiliar terms, such as hides and ploughlands.

[7] The tax assessment in the Domesday Book was known as geld or danegeld and was a type of land-tax based on the hide or ploughland.

The Royal Flying Corps established an airfield near Old Weston to the north of the parish in the First World War which was abandoned in September 1917.

During the Second World War an airfield was built in 1940 and 1941 and named RAF Molesworth; from 1942 it was used by the United States Air Force.

A parish council is responsible for providing and maintaining a variety of local services including allotments and a cemetery; grass cutting and tree planting within public open spaces such as a village green or playing fields.

For Molesworth the highest tier of local government is Cambridgeshire County Council which has administration buildings in Cambridge.

[15] Molesworth is part of the electoral division of Sawtry and Ellington[13] and is represented on the county council by one councillor.

[16] The village, which is approximately 45 metres (148 ft) above sea level, lies just to the north of Junction 16 of the A14 road that runs from the Port of Felixstowe to the Catthorpe Interchange, Leicestershire.

The Anglican church at Molesworth is dedicated to St Peter and is a Grade II listed building standing on the west of the village.