"Mona Lisa Lost Her Smile" is a song written by Johnny Cunningham and recorded by David Allan Coe.
The song is Coe's highest-charting single, with a peak of number two on the U.S. country music charts.
The song is a mid-tempo ballad about a young blonde girl, featuring allusions to the iconic Da Vinci painting.
Thom Jurek of Allmusic described the song favorably in his review, saying that "[t]he layered strings and organ work are slick, but they add such warmth and depth in contrast to Coe's voice that it works to devastating effect.
[1] In Canada, it reached Number One on the RPM Country Tracks charts dated for June 30, 1984.