Monday Creek is a tributary of the Hocking River, 27 miles (43 km) long, in southeastern Ohio in the United States.

[7] The Adena, who lived in the region around 1000 BC, were the earliest known inhabitants of the Monday Creek area.

[11] The earliest white settlements in the area date to 1774; the Ohio Company purchased all the land in the watershed in two installments in 1787 and 1792.

As much as 89% of the Monday Creek watershed was deforested by 1885, with replanting beginning with the establishment of the Wayne National Forest in 1935.

[12] The Ohio Environmental Protection Agency has identified Monday Creek as having been "irretrievably altered to the extent that no appreciable aquatic life can be supported" due to severe contamination by acid mine drainage.