In the main event, Sheamus retained the WWE Championship against John Cena in a Steel Cage match, following an interference from The Nexus.

[10] Three days later, Raw guest host Rob Zombie named his brand's eight competitors: Randy Orton, The Miz, R-Truth, Chris Jericho, Evan Bourne, Ted DiBiase Jr., John Morrison, and Edge.

[11] On the July 5 episode of Raw, The Miz attacked and injured R-Truth; he was taken out of the Money in the Bank match and replaced with Mark Henry the following week.

On June 30, six of the competitors for the SmackDown brand's match were named: Matt Hardy, Kane, Cody Rhodes, Christian, Kofi Kingston, and Big Show.

The main rivalry from the SmackDown brand heading into the Money in the Bank event was between Rey Mysterio and Jack Swagger over the World Heavyweight Championship.

[10] The main rivalry from the Raw brand heading into Money in the Bank was between WWE Champion Sheamus and John Cena.

Sheamus won the title at the Fatal 4-Way event after interference from seven of the contestants from the first season of NXT, collectively known as "The Nexus".

[15] The next night on Raw, John Cena invoked his rematch clause, but The Nexus interrupted the match.

[11] The actual pay-per-view opened with the Money in the Bank ladder match for a World Heavyweight Championship match contract, which involved Big Show, Matt Hardy, Christian, Kane, Kofi Kingston, Cody Rhodes, Drew McIntyre, and Dolph Ziggler.

Midway through the match, Kingston performed a Boom Drop off a ladder on McIntyre through a broadcast table.

In the fourth match, Rey Mysterio faced Jack Swagger for the World Heavyweight Championship.

Kane then chokeslammed an injured Mysterio before executing a Tombstone Piledriver to win the World Heavyweight title in 54 seconds.

In the main event, Sheamus defended the WWE Championship against John Cena in a Steel Cage match.

The Nexus (led by Wade Barrett) interfered with Michael Tarver bringing in Bolt Cutters.

He intercepted Heath Slater and came off and escaped the arena into the crowd, winning the match and retaining the championship.

[21] On the following episode of SmackDown, Rey Mysterio faced Jack Swagger in a two out of three falls match to determine Kane's opponent at SummerSlam.

[21] On the November 22 episode of Raw, The Miz successfully cashed in the briefcase on Randy Orton (who won the title back at Night of Champions) to win the WWE Championship.

[23] A second Money in the Bank event occurred the following year, thus establishing the show as an annual pay-per-view for the promotion,[24] which became simply known as "WWE" in April 2011.