Since 1999, Grütters has been holding an honorary professorship at Freie Universität Berlin for the Master's program Arts and Media Administration.

[1] As an institutional response to the discovery of major artworks of unclear provenance and ownership in the private Gurlitt collection, Grütters launched the German Lost Art Foundation (Deutsches Zentrum Kulturgutverluste) in 2015.

Also in 2015, Grütters presented an amendment to the German law on the protection of cultural property (Kulturgutschutzgesetz) which has been subject to controversial debates.

[2] In the negotiations to form another coalition government under the leadership of Chancellor Angela Merkel following the 2017 federal elections, Grütters led the working group on cultural affairs and media, alongside Dorothee Bär and Michael Roth.

[4] Amid the COVID-19 pandemic in Germany, Grütters led efforts in 2020 to provide government financial help to cultural institutions and artists whose livelihoods were threatened.

[5] Following her party’s defeat in the 2021 elections, Grütters announced her candidacy as Vice President of the Bundestag; however, the CDU/CSU parliamentary group eventually nominated Yvonne Magwas for the position.

[6][7] In September 2024, Grütters announced that she would not stand in the 2025 federal elections but instead resign from active politics by the end of the parliamentary term.

[24] Ahead of the Christian Democrats’ leadership election in 2018, Grütters publicly endorsed Annegret Kramp-Karrenbauer to succeed Angela Merkel as the party’s chair.