[3][4] In her short career, Monisha collaborated with directors such as M. T. Vasudevan Nair, Hariharan, Priyadarshan, Ajayan, Kamal and Sibi Malayil.

[8] Monisha Unni was working on the Malayalam film Cheppadividya when she died in a car accident.

On 5 December 1992, a car carrying Monisha and her mother Sreedevi Unni collided with a KSRTC bus at X-Ray Bypass Junction near Cherthala in Alappuzha district of Kerala.

Monisha, however, died within minutes due to cervical fracture of her spine.

[3][9] Malayalam novelist M. T. Vasudevan Nair, who is also a screenwriter and film director, was a family friend of Monisha.