Monkey Run is an unincorporated community in Baxter County, Arkansas, United States.

[1] The community is on Arkansas Highway 126 approximately 1.5 mile (2.4 km) south of the Ozark Regional Airport and 4.5 miles (7.2 km) west of Mountain Home via Arkansas Highway 178.

Seven different zinc mines operated around Monkey Run, with ore shipped by wagon to Cotter, Arkansas.

The community was originally named Pilgrim's Rest, but was renamed by a storekeeper who watched a group of boys playing tag and exclaimed, "watch them monkeys run".

A later attempt by a vegetable canning plant to change the name to Pleasant Valley never took hold.