Monocacy Station is an unincorporated community that is located in Amity Township in Berks County, Pennsylvania, United States.

This community takes its name from Monocacy Creek, which is a Native American name purported to mean "stream with several big bends".

[2] Monocacy Station is located on North Main Street to the north of the Schuylkill River and east of Birdsboro.

[3] Monocacy Station previously had a post office with a ZIP code of 19542; however, this ZIP code was retired in 2016 and the community is now served by the Douglassville ZIP code of 19518.

[4]