The school district, of which this is the sole comprehensive high school, includes almost all of Monroe, as well as most of High Bridge and Woods Creek; and parts of Chain Lake, Maltby, Monroe North, and Three Lakes.

Examples of these are the academic quiz competition teams, Hi-Q and Knowledge Bowl, and the community service-based Key Club.

Monroe High School's Hi-Q team is a perennial powerhouse and in recent years has consistently made the semifinal and/or final round of the state competition.

Each year, Monroe DECA students serve as base-buddies for the players in the Miracle League games.

Monroe competes in WIAA Class 3A and is a member of the Wesco League in District One.