It is renowned for its food and handicrafts, which are on display at the annual FEXTICUM festival,[3] named in 1973 by Professor Limberg Chero Ballena and held in July during the Fiestas Patrias.

[5][6] Spanish priest Fernando de la Carrera, in his work Arte de la lengua yunga (1644), argues that the word "monsefu" comes from Omænssefæc, meaning "God punishes the one who offends the earth".

[7] Before the arrival of the Spanish, Monsefú would have been part of the chieftainship of Cinto, with the name of Chuspo, whose main center have been located in the vicinity of San Bartolo hill.

[10] After the war, the town was elevated to city level on October 26, 1888 at the request of deputy Manuel María Izaga, under the presidency of Andrés Avelino Cáceres.

[9] The following is a list of mayors of Monsefú since the establishment of a municipal government:[11] It has a varied semitropical temperature, since part of its territory is on the shore of the sea, and another is located in the valley of the Reque River.