Monselice (Italian pronunciation: [monˈseːlitʃe]; Venetian: Monséłexe [moŋˈseɰeze]) is a town and municipality (comune) located in northeastern Italy, in the Veneto region, in the province of Padua about 20 kilometres (12 mi) southwest of the city of Padua, at the southern edge of the Euganean Hills (Colli Euganei).

It lies in the wide plain – a dead level – whereon Ferrara, Bologna, Rovigo, Este, Padua stand and even Venice we could dimly see in the horizon rising with her tiara of proud towers.

In Roman times it was known as Mons Silicis, meaning "mountain of flintstone", possibly due to the local quarries of trachyte.

The Ghibelline leader Ezzelino III da Romano improved the town's fortifications and made it one of the main strongholds of the area.

Important points for tourists can be the central square Piazza Mazzini with the medieval Torre Civica (Civic Tower) and the Palazzo del Monte di Pietà (Public Pawn Palace).

This building hosts the local tourist promotion board (Pro Loco), which provides information for visits to the town's historical attractions.