Monsempron-Libos (French pronunciation: [mɔ̃sɑ̃pʁɔ̃ libɔs]; Occitan: Montsempronh e Libòs) is a commune in the Lot-et-Garonne department in south-western France.

Monsempron-Libos station has rail connections to Périgueux and Agen.

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