[4] In a fictional town named Singletown, three human preteens, with the help of their alien friend, reform the "Monster Buster Club" (often abbreviated as MBC), a secret organization that was founded centuries ago.

While exploring the director Jean-Louis Vandestoc's blog, intriguing information about the early development of Monster Buster Club came to light.

However, Vandestoc mentioned that some images from the pilot were previously accessible on the official Monster Buster Club website before the show's premiere in France.

Monster Buster Club was a collaborative effort between Marathon Media, Mystery Animation, Jetix Europe, TF1, and YTV.

To initiate the production process and establish the show's distinctive artistic style, Max Maléo, the animation supervisor, traveled to India.

Determining a cohesive style proved challenging due to the differing cultural references between India and France, as exemplified by the contrasting popularity of Dragon Ball in the two countries.