Welch has performed and recorded with Duke Robillard, Nick Moss, Johnny Winter, Darrell Nulisch and the Knickerbocker All-Stars, which featured among others, Jimmie Vaughan.

[7] His musical education was helped by his access to his father's record collection, which included work by Magic Sam, Earl Hooker and B.B.

It was the effect of Albert King's work that caused the youngster to gravitate toward the blues, and he learned to play the guitar at the age of eight.

Three years later his parents allowed him access to blues jams and clubs in the Boston area, and he learned further skills from musicians such as Ronnie Earl and Luther "Guitar Junior" Johnson.

"[7] Within a short while the Monster Mike Welch Band was formed with George Lewis on guitar, Jon Ross on bass and Warren Grant on drums.

[10] Adding Insight to Injury was Welch's next solo release in 2004, which included a cover version of Bob Dylan's song "Masters of War".

[11] Welch went on to perform and record with Duke Robillard, Nick Moss, Johnny Winter, Darrell Nulisch and the Knickerbocker All-Stars, which featured Jimmie Vaughan.

[12] In addition, Welch continued to work with Sugar Ray Norcia, more recently issuing Seeing is Believing on Severn Records in October 2016.

[13] In June 2016, Welch and singer Mike Ledbetter took part in a tribute to Otis Rush at the 33rd Chicago Blues Festival.

[17] After a brief hiatus due to the COVID-19 pandemic, Welch announced in February 2023 that he had signed with Gulf Coast Records, with a new solo album, Nothing But Time, to be released on June 30 that year.