Actors who reprised their roles from the film include Reese Witherspoon, Seth Rogen, Will Arnett, and Rainn Wilson.

Each level is divided into multiple stages in which the player takes control of each monster's unique abilities to fight off enemies.

The Missing Link can stick to the sides of large robotic bosses, take control of missile turrets, and outwit his opponents with superior acrobatic skills.

has to solve complex puzzles one step at a time in 3-D mazes, can turn floating plasma generators into personal turrets, slide through grates and use enemies as living key cards/ammunition.

Susan breaks a wall and the monsters escape and disable a giant anti-monster robot known as the US Avenger, but are recaptured by Monger, who is accompanied by a force of soldiers, tanks, and helicopters.