The Mont Grand Matoury Nature Reserve (French: Réserve naturelle nationale du mont Grand Matoury) is a nature reserve in French Guiana, France.

The reserve is located about eight kilometres south of Cayenne in the commune of Matoury[3] It has been named after the eponymous mountain which measures 234 metres (768 ft),[4] It was first protected in 1942,[5] and extended in 2006.

Numerous creeks flow through the area, and the reserve is surrounded by swamps and savannahs.

[6] Mont Grand Matoury Nature Reserve is home to a great variety of wildlife.

In 1995, the palm was rediscovered at Mont Grand Matoury, and is nowadays considered a distinct species.