[2][3] The National Park is located within the Monts du Toura,[3] a range of mountains west of the Sassandra River.

It occupies a rugged terrain in the eastern end of the highland chain extending through Guinea and northern Liberia.

On well-drained soils grasses Brachiaria serrata and Andropogon macrophyllus dominate together with the principal tree species Daniellia oliveri and Lophira lanceloata.

The bird fauna is incompletely surveyed but includes species such as Baumann's olive greenbul and emerald starling.

[5] Herbinger and Lia (unpublished, 2001) carried out a western chimpanzee survey in Mont Sangbe National Park in May 2001, finding a population of 235–260 individuals in a survey area covering less than 5% of the park's total area, a population density of 5.7 chimpanzees per km².